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How to Take Vyvanse

Dosing
  • You should take Vyvanse (lisdexamfetamine dimesylate) once a day in the morning exactly as the doctor tells you to take it.
Taking Vyvanse
  • Vyvanse can be taken with or without food.
  • Vyvanse capsules may be swallowed whole. 
  • If you have trouble swallowing capsules, break open the Vyvanse capsule and pour the powder into a glass of water or orange juice, or mix it with yogurt.
  • Use all of the Vyvanse powder from the capsule so you get all of the medicine.
  • Using a spoon, break apart any powder that is stuck together. Stir the Vyvanse powder with water, orange juice, or yogurt until it is completely mixed together.
  • Eat all the yogurt or drink all the water or orange juice right away after it has been mixed with Vyvanse. Do not store the yogurt, water, or orange juice after it has been mixed with Vyvanse. It is normal to see a filmy coating on the inside of the glass or container after you eat or drink all the Vyvanse.
  • Vyvanse is also available as a chewable tablet. Tablets must be completely chewed before swallowing.
Using Vyvanse Responsibly
  • Store your medicine in a safe place, like a locked cabinet.
  • Do not give Vyvanse to other people, even if they have the same condition. It may harm them. Do not throw away unused Vyvanse in your household trash.

Understanding Safety Information

  • Tell the doctor if you have any kidney problems. Your doctor may lower the Vyvanse dose.
  • Tell the doctor if you are pregnant or plan to be come pregnant. It is not known if Vyvanse may harm your unborn baby.
  • Tell the doctor if you are breastfeeding or plan to breastfeed. Do not breastfeed while taking Vyvanse. Talk to your doctor about the best way to feed your baby if you take Vyvanse.
  • The doctor may do regular checks of your heart and blood pressure while you are taking Vyvanse.
  • If you take too much Vyvanse, call the doctor or poison control center right away, or get to the nearest hospital emergency room.
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Side Effects

Before getting started on Vyvanse, it's important to know the potential risks of treatments.

Tell the doctor if you:

  • have heart problems or heart defects, high blood pressure, or a family history of these problems. This is important because sudden death has occurred in people with heart problems or defects taking stimulant medicines, and sudden death, stroke and heart attack have happened in adults taking stimulant medicines. Since increases in blood pressure and heart rate may occur, the doctor should regularly check these during treatment. Call the doctor right away if you have any signs of heart problems such as chest pain, shortness of breath, or fainting while taking Vyvanse.

  • have mental (psychiatric) problems, or a family history of suicide, bipolar illness, or depression. New or worse behavior and thought problems or new or worse bipolar illness may occur. New psychotic symptoms (such as seeing or hearing things that are not real, believing things that are not true, being suspicious), or new manic symptoms may occur. Call the doctor right away if there are any new or worsening mental symptoms or problems during treatment.

  • have circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud's phenomenon). Fingers or toes may feel numb, cool, painful, sensitive to temperature and/or change color from pale, to blue, to red. Call the doctor right away if any signs of unexplained wounds appear on fingers or toes while taking Vyvanse.

  • have symptoms of serotonin syndrome: agitation hallucinations, coma, or changes in mental status; problems controlling movements or muscle twitching, stiffness, or tightness; fast heartbeat; sweating or fever; nausea, vomiting or diarrhea. Call your doctor or go to the emergency room if symptoms occur. Serotonin syndrome may occur if Vyvanse is taken with certain medicines and may be life-threatening.

Most common side effects with Vyvanse include anxiety, decreased appetite, diarrhea, dizziness, dry mouth, irritability, loss of appetite, nausea, trouble sleeping, upper stomach pain, vomiting, and weight loss. This is not a complete list of potential side effects. For more information, ask your doctor or pharmacist and see Important Safety Information.

If you are experiencing any side effects while taking Vyvanse, let the doctor know

If you are experiencing any side effects while taking Vyvanse, let the doctor know.

Finding The Right Dosage

Your doctor will determine the starting Vyvanse dose and when to make adjustments (a process called titration).

It’s important to work with the doctor to find the dose that’s right for you. The recommended starting dose for Vyvanse is 30 mg once daily in the morning. Your doctor may, if needed, periodically increase or decrease it to control ADHD symptoms and manage side effects. The doctor may sometimes stop treatment to see if Vyvanse is still right for you. 

Convenient, Once-daily Vyvanse Dosing
With 7 strengths of Vyvanse capsules and 6 strengths of chewable tablets, the doctor has the option to customize treatment. You should take Vyvanse exactly as the doctor tells you to take it.

See additional dosing information above.

7 capsule strengths (10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg) Capsules are not shown at actual size | 6 chewable strengths (10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg) Chewable tablets are not shown at actual size

Capsules and chewable tablets are not shown actual size.

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Take an Active Role in Your Treatment

When going to the doctor, here are a few suggestions to help you get the most out of your visit.
For the first visit: For ongoing visits:
  • Talk to the doctor about any side effects you experience or changes in symptoms that you notice.
  • Share any concerns you may have immediately with your doctor.
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IMPORTANT SAFETY INFORMATION

Vyvanse is a federally controlled substance (CII) because it can be abused or lead to dependence. Keep Vyvanse in a safe place to prevent misuse and abuse. Selling or giving away Vyvanse may harm others and is against the law.

Vyvanse is a stimulant medicine. Tell the doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Who should not take Vyvanse?

Do not take Vyvanse if you or your child are:

  • taking or have taken an anti-depression medicine called a monoamine oxidase inhibitor (MAOI) within the past 14 days.
  • sensitive or allergic to, or had a reaction to other stimulant medicines.

Serious problems can occur while taking Vyvanse. Tell the doctor:

  • if you or your child have heart problems, heart defects, high blood pressure, or a family history of these problems. Sudden death has occurred in people with heart problems or defects taking stimulant medicines. Sudden death, stroke and heart attack have happened in adults taking stimulant medicines. Your doctor should check you or your child carefully for heart problems before starting Vyvanse. Since increases in blood pressure and heart rate may occur, the doctor should regularly check these during treatment. Call the doctor right away if you or your child have any signs of heart problems such as chest pain, shortness of breath, or fainting while taking Vyvanse.
  • if you or your child have mental (psychiatric) problems, or a family history of suicide, bipolar illness, or depression. New or worse behavior and thought problems or new or worse bipolar illness may occur. New psychotic symptoms (such as seeing or hearing things that are not real, believing things that are not true, being suspicious) or new manic symptoms may occur. Call the doctor right away if there are any new or worsening mental symptoms or problems during treatment.
  • if you or your child have circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud’s phenomenon). Fingers or toes may feel numb, cool, painful, sensitive to temperature and/or change color from pale, to blue, to red. Call the doctor right away if any signs of unexplained wounds appear on fingers or toes while taking Vyvanse.
  • if your child is having slowing of growth (height or weight). The doctor should check your child’s height and weight often while on Vyvanse, and may stop treatment if a problem is found.
  • if you or your child have symptoms of serotonin syndrome: agitation, hallucinations, coma, or changes in mental status; problems controlling movements or muscle twitching, stiffness, or tightness; fast heartbeat; sweating or fever; nausea, vomiting or diarrhea. Call your doctor or go to the emergency room if symptoms occur. Serotonin syndrome may occur if Vyvanse is taken with certain medicines and may be life-threatening.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are breastfeeding or plan to breastfeed. Do not breastfeed while taking Vyvanse. Talk to your doctor about the best way to feed your baby if you take Vyvanse.

What are possible side effects of Vyvanse?

The most common side effects of Vyvanse in ADHD include:

    • anxiety
    • decreased appetite
    • diarrhea
    • dizziness
    • dry mouth
    • irritability
    • loss of appetite
    • nausea
    • trouble sleeping
    • upper stomach pain
    • vomiting
    • weight loss

The most common side effects of Vyvanse in adults with moderate to severe B.E.D. include:

    • dry mouth
    • trouble sleeping
    • decreased appetite
    • increased heart rate
    • constipation
    • feeling jittery
    • anxiety

For additional safety information, click here for Prescribing Information and Medication Guide and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.
  • if you or your child are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby.