Sharon, a woman with moderate Binge Eating Disorder, smiling.

Sharon, diagnosed with moderate B.E.D. and treated with Vyvanse


See study results in adults with moderate to severe Binge Eating Disorder (B.E.D.)

Learn more about Vyvanse and take a look at its results in clinical studies.

Vyvanse was proven effective in short-term studies

In two 12-week studies of adults who were diagnosed with moderate to severe B.E.D., Vyvanse was proven to reduce the number of weekly binge days (a day with at least 1 binge episode).

At the end of both Study 1 and Study 2, adults with moderate to severe B.E.D. who took Vyvanse experienced, on average, significantly fewer binge days per week compared to those who took placebo. The change in binge days per week for adult patients with moderate to severe B.E.D. from the start of the study to the end was measured using a statistical measure called the LS-Mean.*

*LS-Mean is a statistical method used in the clinical studies to calculate an average score.


reduced the average
number of binge days
per week

On average from the start of the 12-week study to its end.

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Who should not take Vyvanse?

Do not take Vyvanse if you are taking or have taken within the past 14 days an antidepressant called a monoamine oxidase inhibitor (MAOI) or are sensitive to, allergic to, or had a reaction to other stimulant medications.

Concerned about side effects? Talk to your doctor.


Patients taking
Vyvanse had a greater
decrease in obsessive
and compulsive
thoughts and
behaviors about binge
vs patients on
sugar pill

The same 2 studies also looked at obsessive binge eating thoughts and compulsive binge eating behaviors. A tool used by doctors called the Yale-Brown Obsessive Compulsive Scale Modified for Binge Eating (Y-BOCS-BE) measured Vyvanse compared to sugar pill.

Patients treated with Vyvanse had average improvement in the
Y-BOCS-BE total score of 72% and 73%, and patients treated
with sugar pill had improvement of 31% and 34% at the final
visit of each of the 12-week studies.

At the final visit of each of the 12-week studies

During the trials,
doctors said the
majority of patients
"improved" with

In the 2 studies, doctors rated patients as much improved or very much improved ("improved") or "not
improved," using the Clinical Global Impressions—Improvement rating scale (CGI-I).

4-week time period
with no
binge eating episodes

In the 2 studies, the percentage of patients who had no binge eating episodes in the last 4 weeks was measured. This was defined as a patient who experienced no binge eating episodes during the 4 weeks leading up to the patient's last visit of the study. Patients taking Vyvanse were more likely to have no binge eating episodes during this 4-week time period compared to patients taking sugar pill.

  • No binge eating episodes were reported by 40% and 36% of patients taking Vyvanse. By comparison, 14% and 13% of patients taking sugar pill reported no binge eating episodes.

(lisdexamfetamine dimesylate)
was proven effective
in a longer-term study

Vyvanse effectively controlled symptoms in a 38-week study. In this study, patients who initially responded to Vyvanse had a longer time to relapse compared to those who were switched to sugar pill. Relapse was defined as a worsening in both the number of binge eating days (2 or more per week for 2 consecutive weeks) and the symptom severity score determined by the healthcare provider. For patients who continued on Vyvanse, 4% had relapse vs 36% of patients on placebo. Adverse events seen in this study were consistent with those seen in other studies of adult patients with moderate to severe B.E.D. on Vyvanse.

Among patients who continued on Vyvanse, 96% continued to have symptom control. Among patients who were switched to placebo, 68% continued to have symptom control.

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Serious heart-related problems

Serious heart-related problems can occur while taking stimulants, like Vyvanse, including:

  • Sudden death in people who have heart problems or heart defects
  • Sudden death, stroke, and heart attack in adults
  • Increased blood pressure and heart rate

Tell your doctor about any heart problems, heart defects, and/or high blood pressure, or if you have a family history of these problems. Your doctor should check your blood pressure and heart rate regularly during treatment.

Call your doctor right away if you have any signs of heart problems such as chest pain, shortness of breath, or fainting while taking Vyvanse.

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Talking with your doctor

Information that can help you prepare for your conversation.

Vyvanse® dosing Icon.

How to take Vyvanse

Learn about Vyvanse dosing.