Vyvanse for adults with ADHD

Learn How Vyvanse® Treats ADHD in Adults

Patient portrayal

Learning about treatment for adults with Attention-Deficit/Hyperactivity Disorder (ADHD)? You probably have some questions. Does it improve attention? How long does it last? What are the potential side effects? Ask your doctor and check the results below.

Vyvanse® is the #1 Prescribed Branded ADHD Medication

ADHD in adults is a treatable medical disorder

Ask your doctor if Vyvanse could offer you consistent symptom improvement. This discussion guide can help.

Talk to your doctor

Vyvanse clinical study results

Vyvanse may help increase attention and decrease impulsiveness and hyperactivity in adults with ADHD. Your doctor may prescribe Vyvanse as part of a total treatment program that may include counseling or other therapies.

Vyvanse® Clinical Study Results

Understanding the research

The study

Vyvanse® Study Population

1 Study population

142 adults aged 18 to 55 with ADHD

Vyvanse® Study Dose Selection

2 Dose selection

For the first 4 weeks, everyone in the study took Vyvanse. Researchers adjusted the dose as needed to find the right dose for each person.

Vyvanse® Study Groups

3 Study groups

At the beginning of the fifth week, half of the group continued to take Vyvanse. The other half switched to sugar pill (placebo). Researchers and subjects didn’t know who got Vyvanse and who got the sugar pill.

Vyvanse® Study Setting

4 Study setting

At the end of the fifth week, during a single day, both groups were placed in a classroom-like setting designed to resemble the workplace environment.

Vyvanse® Study Testing

5 Testing

At 7am, everyone took their assigned medication—either Vyvanse or the sugar pill. Next, they began a schedule of general activities that were designed to keep study subjects busy and bring out symptoms of ADHD. After each set of activities, subjects were given a timed test* commonly used by researchers to measure attention in ADHD. Tests were given over 14 hours at 9 AM, 11 AM, 3 PM, 5 PM, and 7 PM; the last test was at 9 PM.


*Permanent Product Measure of Performance (PERMP) is a skill-adjusted test that measures attention to ADHD.

Vyvanse® Study Testing Repeated

6 Testing repeated

At the beginning of the sixth week, the group that had taken Vyvanse was switched to the sugar pill and the group that had taken the sugar pill was switched to Vyvanse. At the end of the sixth week, study subjects were again given the timed tests under the same conditions.

Vyvanse® Study Measures

7 Measures

Attention was measured by using the groups’ average test scores throughout the day when taking Vyvanse compared to when taking the sugar pill. Higher scores indicated improved attention.

Study results

The average of all test scores throughout the day was higher when Vyvanse was taken.

Vyvanse improved attention throughout the day for each time point tested, starting at 2 hours and even at 14 hours after taking it.

*Efficacy measured using the Permanent Product Measure of Performance (PERMP), a skill-adjusted test that measures attention in ADHD.

Clinical trial chart shows Vyvanse® improved attention throughout the day for Adults with ADHD

Who should not take Vyvanse (lisdexamfetamine dimesylate)

Do not take Vyvanse if you are taking or have taken within the past 14 days an anti-depression medicine called a monoamine oxidase inhibitor, or MAOI, or are sensitive to, allergic to, or had a reaction to other stimulant medications. Concerned about side effects? Talk to your Doctor.

Learn more

Vyvanse® Clinical Study Results

Understanding the research

Vyvanse is approved for maintenance treatment in adults

The study

Vyvanse® Study Population

1 Study population

123 adults aged 18 to 55 with ADHD who were taking Vyvanse for at least 6 months. Patients must have demonstrated a response to treatment with Vyvanse.

Vyvanse® Study Groups

2 Study groups

After 3 weeks of observation while on Vyvanse, about half of the patients continued to take Vyvanse for the last 6 weeks of the study while the other half were switched to a sugar pill.

Study results

At the end of the study, 91% of people maintained symptom control with Vyvanse versus 25% with a sugar pill.

Clinical trial chart shows 91% of adults maintained ADHD symptom control with Vyvanse® versus 25% with a sugar pill.

Treatment failure was defined as a ≥50% increase (worsening) in the ADHD Rating Scale IV (ADHD-RS-IV) Total Score and ≥2-point increase in the Clinical Global Impression Severity (CGI-S) score compared to scores at entry into the double-blind phase.

Vyvanse (lisdexamfetamine dimesylate) May Not Be Right for Everyone

Vyvanse should be taken exactly as prescribed by your doctor. Before starting Vyvanse and during treatment, tell your doctor about all health conditions (or family history of) including:

  • Any previous or current abuse or dependency on alcohol, prescription medicine, or street drugs
  • Heart problems, heart defects, or high blood pressure
  • Mental problems, including psychosis, mania, bipolar illness, or depression
  • Circulation problems in fingers and toes
  • If you have any kidney problems. Your doctor may lower the dose
  • If you are pregnant or plan to become pregnant. It is not known if Vyvanse may harm your unborn baby
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed while taking Vyvanse. Talk to your doctor about the best way to feed your baby if you take Vyvanse
Next up?

Did you know you can take Vyvanse 5 different ways?

Want info about Vyvanse for ADHD in children (ages 6-17)?

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